clonal selection theory

клонально-селекционная теория
Теория, объясняющая механизм возникновения специфических антител antibody к неограниченному числу антигенов: их образование происходит в результате рекомбинации генов, кодирующих вариабельную variable part и константную constant part части иммуноглобулинов, что приводит к образованию большого числа функционирующих генов в популяции незрелых В-лимфоцитов, причем в каждой отдельной клетке экспрессируется лишь одна комбинация генов; при появлении антигена клетка, вырабатывающая взаимодействующее с ним антитело (иммуноглобулин), избирательно стимулируется к делению в ответ на сигнал, образуемый при контакте антигена с рецептором (иммуноглобулином) на поверхности клетки; в результате пролиферации образуется клон лимфоцитов, синтезирующих антитела требуемой специфичности.

Англо-русский толковый словарь генетических терминов. — М.: Изд-во ВНИРО. . 1995.

Смотреть что такое "clonal selection theory" в других словарях:

  • clonal selection theory — clonal selection theory. См. клонально селекционная теория. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • clonal selection theory — a modification of the natural selection theory (q.v.): there are in each adult several million clones of antibody producing cells, each programmed to make antibody of a single specificity and bearing cell surface receptors capable of reacting… …   Medical dictionary

  • clonal deletion theory — a theory of immunologic tolerance to self antigens according to which “forbidden clones” of immunocytes, those reactive with self antigens, are eliminated on contact with antigen during fetal life. The terms “clonal abortion,” “clonal… …   Medical dictionary

  • Clonal selection — of lymphocytes: 1) A hematopoietic stem cell undergoes differentiation and genetic rearrangement to produce 2) immature lymphocytes with many different antigen receptors. Those that bind to 3) antigens from the body s own tissues are destroyed,… …   Wikipedia

  • Clonal Selection Algorithm — In Artificial immune systems, Clonal selection algorithms are a class of algorithms inspired by the clonal selection theory of acquired immunity that explains how B and T lymphocytes improve their response to antigens over time called affinity… …   Wikipedia

  • natural selection theory — the first selective theory of antibody formation, according to which about a million different antibody molecules are constantly being produced at low levels; when an antibody combines with a complementary antigen the complex is taken up by… …   Medical dictionary

  • Clonal — may refer to in Immunology Clonal deletion, a process by which B cells and T cells are deactivated before act significantly upon specific antigens Clonal selection theory, a model for how the immune system responds to infection Clonal anergy, a… …   Wikipedia

  • theory — A reasoned explanation of known facts or phenomena that serves as a basis of investigation by which to seek the truth. SEE ALSO: hypothesis, postulate. [G. theoria, a beholding, speculation, t., fr. theoros, a beholder] adsorption t. of narcosis… …   Medical dictionary

  • Ehrlich's theory — Ehrlich s side chain theory the first (1896) comprehensive theory of antibody production, which proposed that antibody producing cells have surface molecules (side chains) that can bind to antigens and that binding to a specific side chain causes …   Medical dictionary

  • Kin selection — From the time of antiquity field biologists have observed that some organisms tend to exhibit strategies that favor the reproductive success of their relatives, even at a cost to their own survival and/or reproduction. The classic example is a… …   Wikipedia

  • Signalling theory — Within evolutionary biology, signalling theory refers to a body of theoretical work examining communication between individuals. The central question is when animals with conflicting interests should be expected to communicate honestly .… …   Wikipedia


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